The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2012
Filed:
Mar. 12, 2009
Peter T. Lansbury, Jr., Brookline, MA (US);
Craig J. Justman, Cambridge, MA (US);
Ross A. Fredenburg, Cambridge, MA (US);
Robin Kate Meray, Cambridge, MA (US);
Mark E. Duggan, Wellesley, MA (US);
Peter Lin, Edison, NJ (US);
Peter T. Lansbury, Jr., Brookline, MA (US);
Craig J. Justman, Cambridge, MA (US);
Ross A. Fredenburg, Cambridge, MA (US);
Robin Kate Meray, Cambridge, MA (US);
Mark E. Duggan, Wellesley, MA (US);
Peter Lin, Edison, NJ (US);
Link Medicine Corporation, Cambridge, MA (US);
Abstract
Novel quinolinone farnesyl transferase inhibitors are provided. These new compounds are useful in the treatment or prevention of synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease, multiple system atrophy, and disorders of brain iron concentration including pantothenate kinase-associated neurodegeneration (e.g., PANK1), or other neurodegenerative/neurological diseases. Provided compounds are also useful in the treatment of proliferative diseases such as cancer, and in the treatment of neurological diseases, such as cognitive impairment, depression, and anxiety. The treatment including administering to a subject a therapeutically effective amount of an inventive farnesyl transferase inhibitor compound.