The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2012
Filed:
Jun. 10, 2009
Peter X. Wang, Chesterfield, MO (US);
Frank W. Moser, Arnold, MO (US);
Christopher W. Grote, Webster Groves, MO (US);
Gary L. Cantrell, Troy, IL (US);
Peter X. Wang, Chesterfield, MO (US);
Frank W. Moser, Arnold, MO (US);
Christopher W. Grote, Webster Groves, MO (US);
Gary L. Cantrell, Troy, IL (US);
Mallinckrodt LLC, Hazelwood, MO (US);
Abstract
The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POClthat is necessary to form the 3,4-dihydroisoquinoline.