The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2012
Filed:
Jul. 30, 2009
Applicants:
Stefano Turchetta, Patrica, IT;
Lorenzo DE Ferra, Patrica, IT;
Maurizio Zenoni, Patrica, IT;
Mauro Anibaldi, Patrica, IT;
Inventors:
Stefano Turchetta, Patrica, IT;
Lorenzo De Ferra, Patrica, IT;
Maurizio Zenoni, Patrica, IT;
Mauro Anibaldi, Patrica, IT;
Assignee:
Chemi S.p.A., Cinisello Balsamo (MI), IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 233/66 (2006.01);
U.S. Cl.
CPC ...
Abstract
Described is a new process for producing temozolomide, comprising the reaction between 5-aminoimidazole-4-carboxamide and N-succinimidyl-N'-methyl carbamate and the subsequent reaction of the thus obtained carbamoyl 5-aminoimidazole-4-carboxamide with sodium nitrite. Temozolomide is then purified by chromatography on adsorbent polymeric resin and subsequent crystallization from water and acetone.