The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2012
Filed:
Aug. 17, 2010
Julian Paul Henschke, Summertown, AU;
Xiaoheng Zhang, Lianyungang, CN;
Guodong Chu, Jiaxiang County, CN;
Lijun Mei, Taihe County, CN;
Yung Fa Chen, Chiali, TW;
Julian Paul Henschke, Summertown, AU;
Xiaoheng Zhang, Lianyungang, CN;
Guodong Chu, Jiaxiang County, CN;
Lijun Mei, Taihe County, CN;
Yung Fa Chen, Chiali, TW;
ScinoPharm Taiwan, Ltd., Tainan, TW;
Abstract
A process for the preparation of cladribine of API grade is provided by direct coupling of O-protected 2-deoxy-ribofuranose with silylated 2-chloroadenine followed by deprotection of the resultant protected nucleoside in a separate step and then a purification step. Following the coupling, the desired N-9-glycosylated β-anomer of the nucleoside is directly isolated as a solid from the coupling reaction mixture by filtration in relatively high purity and yield, and it does not require purification.