The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2012
Filed:
May. 16, 2007
Yasunori Chiba, Ibaraki, JP;
Yoshifumi Jigami, Ibaraki, JP;
Kosuke Kuroda, Gunma, JP;
Kazuo Kobayashi, Gunma, JP;
Kimihisa Ichikawa, Tokyo, JP;
Koichi Nonaka, Fukushima, JP;
Takeshi Suzuki, Fukushima, JP;
Yasunori Chiba, Ibaraki, JP;
Yoshifumi Jigami, Ibaraki, JP;
Kosuke Kuroda, Gunma, JP;
Kazuo Kobayashi, Gunma, JP;
Kimihisa Ichikawa, Tokyo, JP;
Koichi Nonaka, Fukushima, JP;
Takeshi Suzuki, Fukushima, JP;
National Institute of Advanced Industrial Science and Technology, Tokyo, JP;
Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;
Daiichi Sankyo Company, Limited, Tokyo, JP;
Abstract
This invention provides a means for enabling high-level secretory production of proteins, in particular proteins having complicated structures such as antibodies, in host cells such as yeast cells. The invention also provides transformed yeast cells having the activated HAC1 gene and the RRBP1 gene and a method for enabling high-level secretory production of foreign proteins using such transformed host cells by inhibiting O-sugar chain formation indigenous to host cells such as yeast cells.