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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8232312 B1

PDFFull Text
Date of Patent:
Jul. 31, 2012

Filed:

Mar. 14, 2008

Substituted arylsulphonylglycines, the preparation thereof and the use thereof as pharmaceutical compositions

Applicants:

Holger Wagner, Mettenberg, DE;

Elke Langkopf, Warthausen, DE;

Matthias Eckhardt, Biberach, DE;

Ruediger Streicher, Biberach, DE;

Corinna Schoelch, Mittelbiberach, DE;

Annette Schuler-metz, Ulm, DE;

Alexander Pautsch, Ulm, DE;

Inventors:

Holger Wagner, Mettenberg, DE;

Elke Langkopf, Warthausen, DE;

Matthias Eckhardt, Biberach, DE;

Ruediger Streicher, Biberach, DE;

Corinna Schoelch, Mittelbiberach, DE;

Annette Schuler-Metz, Ulm, DE;

Alexander Pautsch, Ulm, DE;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:

Michael P. Morris

David L. Kershner

Usha R. Patel

Primary Examiner:

Joseph Kosack

Assistant Examiner:

Matthew Coughlin

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/497 (2006.01); A61K 31/496 (2006.01); A61K 31/454 (2006.01); A61K 31/4439 (2006.01); A61K 31/428 (2006.01); A61K 31/4184 (2006.01); A61K 31/416 (2006.01); A61K 31/404 (2006.01); C07D 413/06 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 277/64 (2006.01); C07D 333/60 (2006.01); C07D 235/26 (2006.01); C07D 235/08 (2006.01); C07D 231/56 (2006.01); C07D 209/42 (2006.01); C07D 209/08 (2006.01); C07D 209/88 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to substituted arylsulphonylglycines of general formula (I) wherein R, X, Y and Z are defined as in claim, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.

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