The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2012
Filed:
Jul. 03, 2008
Glenn R. Larsen, Sudbury, MA (US);
Dianne S. Sako, Boston, MA (US);
Xiao-jia Chang, Newton Centre, MA (US);
Geertruida M. Veldman, Sudbury, MA (US);
Dale Cumming, Acton, MA (US);
Ravindra Kumar, Belmont, MA (US);
Gray Shaw, Cambridge, MA (US);
Glenn R. Larsen, Sudbury, MA (US);
Dianne S. Sako, Boston, MA (US);
Xiao-Jia Chang, Newton Centre, MA (US);
Geertruida M. Veldman, Sudbury, MA (US);
Dale Cumming, Acton, MA (US);
Ravindra Kumar, Belmont, MA (US);
Gray Shaw, Cambridge, MA (US);
Genetics Institute, LLC, Cambridge, MA (US);
Abstract
A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.