The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2012
Filed:
Oct. 15, 2003
Kent Jardemark, Gothenburg, SE;
Aldo Jesorka, Gothenburg, SE;
Mattias Karlsson, Gothenburg, SE;
Jessica Olofsson, Gothenburg, SE;
Owe Orwar, Hovas, SE;
Johan Pihl, Gothenburg, SE;
Eskil Sahlin, Gothenburg, SE;
Kent Jardemark, Gothenburg, SE;
Aldo Jesorka, Gothenburg, SE;
Mattias Karlsson, Gothenburg, SE;
Jessica Olofsson, Gothenburg, SE;
Owe Orwar, Hovas, SE;
Johan Pihl, Gothenburg, SE;
Eskil Sahlin, Gothenburg, SE;
Cellectricon AB, Gothenburg, SE;
Abstract
The present invention relates to methods of measuring electrical properties of a cell using electrode devices comprising tapered nanotips having submicrometer dimensions ('nanoelectrodes') for insertion into a cell. The devices are used to measure electrical properties of the cell and, optionally, may be used to electroporate, the cell or subcellular structures within the cell. The invention also provides arrays of electrode devices having nanotips for simultaneously or sequentially measuring the electrical properties of cells (e.g., such as surface immobilized cells). The electrodes can be used to measure properties of ion channels and in HTS assays to identify drugs which affect the properties of ion channels. The invention additionally provides microfluidic systems adapted for use with the electrode devices having nanotips. In combination with the electrodes, the microfluidic systems provide cell-based biosensors for monitoring cellular responses to conditions, such as exposure to candidate drugs.