The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Apr. 29, 2009
Zhengyan Cai, Shanghai, CN;
Weicheng Zhou, Shanghai, CN;
Qun Hao, Shanghai, CN;
Zhenhua Shi, Shanghai, CN;
Yuchen Sheng, Shanghai, CN;
Mingyu Shi, Shanghai, CN;
Qingning Liang, Shanghai, CN;
Zhengyan Cai, Shanghai, CN;
Weicheng Zhou, Shanghai, CN;
Qun Hao, Shanghai, CN;
Zhenhua Shi, Shanghai, CN;
Yuchen Sheng, Shanghai, CN;
Mingyu Shi, Shanghai, CN;
Qingning Liang, Shanghai, CN;
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
Abstract
The present invention discloses a quinoline compound represented by the formula A or pharmaceutically acceptable solvate, optical isomer or polymorph thereof, wherein X is S or O; M is H, Na, NH4or Ca; each of R, Rand Ris independently H, halogen, the group represented by formula D or formula E; R is H, halogen, C1˜C4 alkyl or C1˜C4 alkoxy. The present invention also discloses its pharmaceutical composition and the preparation method thereof and application in manufacturing a medicament for inhibiting HMG-CoA reductase or for the treatment and prophylaxis of the diseases which can be treated effectively by inhibiting HMG-CoA reductase. The quinloline compound and pharmaceutical composition thereof of the present invention have an excellent lipid reduction effect in vivo and can be applied for treatment of a hyperlipidemia-related disease.