The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Jun. 10, 2009
Gary L. Cantrell, Troy, IL (US);
Dan P. Magparangalan, Gainesville, FL (US);
Frank W. Moser, Arnold, MO (US);
Jian Bao, Chesterfield, MO (US);
Christopher W. Grote, Webster Groves, MO (US);
Peter X. Wang, Chesterfield, MO (US);
Gary L. Cantrell, Troy, IL (US);
Dan P. Magparangalan, Gainesville, FL (US);
Frank W. Moser, Arnold, MO (US);
Jian Bao, Chesterfield, MO (US);
Christopher W. Grote, Webster Groves, MO (US);
Peter X. Wang, Chesterfield, MO (US);
Mallinckrodt LLC, Hazelwood, MO (US);
Abstract
The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.