The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Jul. 16, 2007
Alexander B. Maurer, Bad Homburg, DE;
Sascha Hoevelmann, Frankfurt am Main, DE;
Elke Martin, Karlsruhe, DE;
Bernd Hentsch, Duisburg, DE;
Michael Gassen, Munich, DE;
Juergen Kraus, Starnberg, DE;
Rolf Krauss, Planegg-Martinsried, DE;
Adam-spencer Vincek, Gainesville, FL (US);
Alexander B. Maurer, Bad Homburg, DE;
Sascha Hoevelmann, Frankfurt am Main, DE;
Elke Martin, Karlsruhe, DE;
Bernd Hentsch, Duisburg, DE;
Michael Gassen, Munich, DE;
Juergen Kraus, Starnberg, DE;
Rolf Krauss, Planegg-Martinsried, DE;
Adam-Spencer Vincek, Gainesville, FL (US);
4SC Discovery GmbH, Planegg-Martinsried, DE;
Abstract
The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.