The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Jun. 27, 2011
David M. Weiner, San Diego, CA (US);
Robert E. Davis, San Diego, CA (US);
Mark R. Brann, Rye, NH (US);
Carl-magnus A. Andersson, Hjärup, SE;
Allan K. Uldam, Vaerloese, DE;
David M. Weiner, San Diego, CA (US);
Robert E. Davis, San Diego, CA (US);
Mark R. Brann, Rye, NH (US);
Carl-Magnus A. Andersson, Hjärup, SE;
Allan K. Uldam, Vaerloese, DE;
ACADIA Pharmaceuticals Inc., San Diego, CA (US);
Abstract
Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.