The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Jun. 08, 2007
Masahiko Hagihara, Ube, JP;
Yasunori Tsuzaki, Ube, JP;
Ken-ichi Komori, Ube, JP;
Hiroshi Nishida, Ube, JP;
Kazutaka Kido, Ikoma, JP;
Tomokazu Fujimoto, Ikoma, JP;
Takeshi Matsugi, Ikoma, JP;
Atsushi Shimazaki, Ikoma, JP;
Masahiko Hagihara, Ube, JP;
Yasunori Tsuzaki, Ube, JP;
Ken-ichi Komori, Ube, JP;
Hiroshi Nishida, Ube, JP;
Kazutaka Kido, Ikoma, JP;
Tomokazu Fujimoto, Ikoma, JP;
Takeshi Matsugi, Ikoma, JP;
Atsushi Shimazaki, Ikoma, JP;
Ube Industries, Ltd., Yamaguchi, JP;
Santen Pharmaceutical Co., Ltd., Osaka, JP;
Abstract
An object of the present invention is to create a novel indazole derivative having a spiro ring structure in a side chain, which is useful as a pharmaceutical, and to find a new pharmacological activity of the derivative. The present invention compound is represented by the general formula [I] and has an excellent Rho kinase inhibitory activity. In the formula, the ring X represents a benzene ring or a pyridine ring; Rand Rrepresent halogen, H, OH, alkoxy, cycloalkyloxy, aryloxy, alkyl, cycloalkyl or the like; Rrepresents halogen, H or the like; Rand Rrepresent halogen, H or the like; Rand Rrepresent H, alkyl or the like; and m, n, p and q represent an integer of 0 to 3. In this connection, each group may have a substituent.