The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Oct. 13, 2010
Ian Maclachlan, Mission, CA;
Adam Judge, Vancouver, CA;
Snorri S. Thorgeirsson, Bethesda, MD (US);
Yun-han Lee, Rockville, MD (US);
Ian MacLachlan, Mission, CA;
Adam Judge, Vancouver, CA;
Snorri S. Thorgeirsson, Bethesda, MD (US);
Yun-Han Lee, Rockville, MD (US);
Protiva Biotherapeutics, Inc., Burnaby, BC, CA;
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Abstract
The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.