The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Nov. 17, 2009
Dehua Liu, Beijing, CN;
Hongjuan Liu, Beijing, CN;
Xianjin Ou, Beijing, CN;
Yan Sun, Beijing, CN;
Yunzhen Xu, Beijing, CN;
Yueyong Lei, Yiyang, CN;
Weibin Liu, Yiyang, CN;
Dehua Liu, Beijing, CN;
Hongjuan Liu, Beijing, CN;
Xianjin Ou, Beijing, CN;
Yan Sun, Beijing, CN;
Yunzhen Xu, Beijing, CN;
Yueyong Lei, Yiyang, CN;
Weibin Liu, Yiyang, CN;
Tsinghua University, Beijing, CN;
Hunan Rivers Biotechnology Co. Ltd., Yiyang, CN;
Abstract
The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught.