The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
May. 18, 2005
Anthony O. Caggiano, Larchmont, NY (US);
Elliott A. Gruskin, Killington, CT (US);
Yelena G. Sheptovitsky, Stamford, CT (US);
Sarah Kasperbauer, Cortlandt Manor, NY (US);
Anthony O. Caggiano, Larchmont, NY (US);
Elliott A. Gruskin, Killington, CT (US);
Yelena G. Sheptovitsky, Stamford, CT (US);
Sarah Kasperbauer, Cortlandt Manor, NY (US);
Acorda Therapeutics, Inc., Hawthorne, NY (US);
Abstract
An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase.