The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2012
Filed:
Apr. 05, 2010
E. Peter Greenberg, Seattle, WA (US);
Josephine R. Chandler, Seattle, WA (US);
Breck Duerkop, Dallas, TX (US);
Patricia Silva Lima, Duque de Caxias, BR;
Joshua Alan Blodgett, Boston, MA (US);
Jon Clardy, Boston, MA (US);
Mohammad R. Seyedsayamdost, Newton, MA (US);
E. Peter Greenberg, Seattle, WA (US);
Josephine R. Chandler, Seattle, WA (US);
Breck Duerkop, Dallas, TX (US);
Patricia Silva Lima, Duque de Caxias, BR;
Joshua Alan Blodgett, Boston, MA (US);
Jon Clardy, Boston, MA (US);
Mohammad R. Seyedsayamdost, Newton, MA (US);
University of Washington through its Center for Commercialization, Seattle, WA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic locus of the bactobolin analog in(bta cluster) or a homolog structure (at least 95% sequence identity) thereof, and further isolation and purification of the bactobolin analog. For example, the bacterial strain can be a wild type bacterial strain such as astrain comprising a bta cluster (e.g.(e.g. E264, Bt4, and TXDOH) and(e.g. K96243, 1106a, and 1106b).