The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 17, 2012

Filed:

May. 17, 2006
Applicants:

Gabriel Galvin, Emeryville, CA (US);

Eric Harwood, Emeryville, CA (US);

David Ryckman, Emeryville, CA (US);

Shuguang Zhu, Emeryville, CA (US);

Inventors:

Gabriel Galvin, Emeryville, CA (US);

Eric Harwood, Emeryville, CA (US);

David Ryckman, Emeryville, CA (US);

Shuguang Zhu, Emeryville, CA (US);

Assignee:

Novartis AG, Emeryville, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/00 (2006.01); C07D 403/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A method for synthesizing a heterocyclic compound includes: reacting 1-methylpiperazine with 5-chloro-2-nitroaniline at an internal temperature sufficient to provide a compound of Formula VIH The 1-methylpiperazine and the 5-chloro-2-nitroaniline are reacted in a solvent that comprises water in an amount greater than 50 percent by volume based on the amount of the solvent and/or are reacted in a solvent that comprises an organic solvent component that has a boiling point of greater than 100° C. at atmospheric pressure.


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