The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2012
Filed:
Jul. 07, 2008
Hiroko Kusano, Tokyo, JP;
Dinesh Shyamdeo Mishra, Carmel, IN (US);
Yoshikazu Tashiro, Tokyo, JP;
Yosuke Watanabe, Tokyo, JP;
Hong Zhuang, Zionsville, IN (US);
Hiroko Kusano, Tokyo, JP;
Dinesh Shyamdeo Mishra, Carmel, IN (US);
Yoshikazu Tashiro, Tokyo, JP;
Yosuke Watanabe, Tokyo, JP;
Hong Zhuang, Zionsville, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;
Abstract
The present invention provides formulation parameters and manufacturing conditions for stable pharmaceutical compositions comprising N-{4-(2,2-dimethyl-propionyl)-(5R)-5-[(2-ethylamino-ethanesulfonylamino)-methyl]-5-phenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-2,2-dimethyl-propionamide that minimize undesirable chiral conversion to the less active S enantiomeric form.