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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8222274 B1

PDFFull Text
Date of Patent:
Jul. 17, 2012

Filed:

Feb. 19, 2007

Pyrrole derivative or salt thereof

Applicants:

Ryushi Seo, Tokyo, JP;

Hidetaka Kaku, Tokyo, JP;

Hiroyoshi Yamada, Tokyo, JP;

Daisuke Kaga, Tokyo, JP;

Shinobu Akuzawa, Tokyo, JP;

Inventors:

Ryushi Seo, Tokyo, JP;

Hidetaka Kaku, Tokyo, JP;

Hiroyoshi Yamada, Tokyo, JP;

Daisuke Kaga, Tokyo, JP;

Shinobu Akuzawa, Tokyo, JP;

Assignee:

Astellas Pharma Inc., Tokyo, JP;

Attorney:

Fitzpatrick, Cella, Harper & Scinto

Primary Examiner:

Fiona T Powers

Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 207/327 (2006.01); C07D 401/04 (2006.01); C07D 403/06 (2006.01); C07D 405/06 (2006.01); C07D 405/04 (2006.01); C07D 403/12 (2006.01); C07D 409/04 (2006.01); C07D 409/12 (2006.01); C07D 413/04 (2006.01); A61K 31/40 (2006.01); A61K 31/4025 (2006.01); A61K 31/422 (2006.01); A61K 31/439 (2006.01); A61K 31/454 (2006.01); A61P 1/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

[Problem] To provide a compound which may be used for the prevention and/or treatment of diseases in which 5-HTreceptor and 5-HTreceptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS). [Means for Resolution] It was found that a pyrrole derivative characterized by the possession of a guanidinocarbonyl group or amido group as a substituent group at the 3-position, or a pharmaceutically acceptable salt thereof, has a strong antagonism for both of the 5-HTreceptor and 5-HTreceptor. In addition, the compound of the present invention having the antagonistic activity for both of the receptors showed a good pharmacological action in comparison with the case in which an antagonist selective for either one of the receptors was used alone. Based on the above, the compound of the present invention is useful for the prevention and/or treatment of diseases in which 5-HTreceptor and 5-HTreceptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS).

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