The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2012
Filed:
Jun. 07, 2006
Rémi Lemaire, Ormesson sur Marne, FR;
Isabelle Fournier, Bourghelles, FR;
Michel Salzet, Bourghelles, FR;
Michel Dechamps, Verviers, BE;
Jean-claude Edmond Tabet, Morangis, FR;
Gottfried Proess, Butgenbach, BE;
Ivo Rudloff, Essen, DE;
Marc Lemaitre, Cincinnati, OH (US);
Rémi Lemaire, Ormesson sur Marne, FR;
Isabelle Fournier, Bourghelles, FR;
Michel Salzet, Bourghelles, FR;
Michel Dechamps, Verviers, BE;
Jean-Claude Edmond Tabet, Morangis, FR;
Gottfried Proess, Butgenbach, BE;
Ivo Rudloff, Essen, DE;
Marc Lemaitre, Cincinnati, OH (US);
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Universite des Sciences et Technologies de Lille, Villeneuve d'Ascq, FR;
Eurogentec S.A., Seraing, FR;
Abstract
The invention concerns a method for determining at least one target molecule map in a tissue section, using at least one (A-X)n-B conjugate, wherein A is a tag molecule of known molecular weight, X is a linker that is cleaved during sample desorption/ionization, n is an integer of at least 1, and B is a binding molecule that binds specifically to said target molecule. When using MALDI mass spectrometry, said linker molecule X may be cleaved by photodissociation during sample laser irradiation if photocleavable at the wavelength of said MALDI laser. Alternatively, when using UV-MALDI, IR-MALDI, SIMS or DESI mass spectrometry, said linker molecule X may be cleaved by fragmentation during sample desorption/ionization.