The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2012
Filed:
Feb. 27, 2008
Nisar Malek, Hannover, DE;
Florenz Sasse, Braunschweig/Leiferde, DE;
Irina Nickeleit, Barnstorf, DE;
Roland Frank, Meine, DE;
Bettina Hinkelmann, Braunschweig, DE;
Heinrich Steinmetz, Hildesheim, DE;
Nisar Malek, Hannover, DE;
Florenz Sasse, Braunschweig/Leiferde, DE;
Irina Nickeleit, Barnstorf, DE;
Roland Frank, Meine, DE;
Bettina Hinkelmann, Braunschweig, DE;
Heinrich Steinmetz, Hildesheim, DE;
Helmholtz Zentrum für Infektionsforschung GmbH, Braunschweig, DE;
Medizinische Hochschule Hannover, Hannover, DE;
Abstract
The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular Argyrin and derivatives thereof, preferably Argyrin A, for the treatment of proliferative diseases, such as cancer, as well as the derivatization of said macrocycles.