The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2012
Filed:
Apr. 16, 2008
Shigeru Yonekubo, Azumino, JP;
Takashi Miyagi, Azumino, JP;
Kohsuke Ohno, Azumino, JP;
Mikie Kambara, Azumino, JP;
Nobuhiko Fushimi, Azumino, JP;
Shigeru Yonekubo, Azumino, JP;
Takashi Miyagi, Azumino, JP;
Kohsuke Ohno, Azumino, JP;
Mikie Kambara, Azumino, JP;
Nobuhiko Fushimi, Azumino, JP;
Kissei Pharmaceutical Co., Ltd., Nagano, JP;
Abstract
[Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; Rand Rare independently halogen, cyano, alkyl, alkylsulfonyl, —OW, —SW, —COW, —NWW, —SONWW, aryl, etc.; Ris H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, —CO—Y, —SO—Y, —S-(alkylene)-Y, —O-(alkylene)-Y, —SO-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.