The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2012
Filed:
Aug. 17, 2007
Harri Takalo, Turku, FI;
Jouko Kankare, Turku, FI;
Elina Tienari, Espoo, FI;
Abacus Diagnostica Oy, Turku, FI;
Abstract
The invention relates to a detectable molecule comprising a biospecific binding reactant attached to a luminescent lanthanide chelate comprising a lanthanide ion and a chelating ligand of the formula (I) wherein, RRare independently of each other selected from the group consisting of hydrogen, methyl, ethyl, —COOH, —COO—, —CHCOOH, —CHCOO—, hydroxyl or OR; Ris selected from the group consisting of —CH, —C(CH), —C(CR), wherein Ris an alkyl with 1 to 6 carbon atoms, —CHCOOH, —CHCOO, and appropriate hexose residues; Ris a linker for coupling to a biospecific binding reactant selected from the group consisting of thiourea (—NH—CS—NH—), aminoacetamide (—NH—CO—CH—NH—), amide (—NH—CO— and —CO—NH—), aliphatic thioether (—S—), disulfide (—S—S—) and 6-substituted-1,3,5-triazine-2,4-diamine; and the lanthanide ion is selected from the group consisting of europium(III), terbium(III), dysprosium(III) and samarium(III). The invention also relates to corresponding lanthanide chelates. The invention further relates to the use of the detectable molecule of the invention.