The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2012
Filed:
Aug. 27, 2007
Michael Houghton, Danville, CA (US);
Yin-ling Lin, Emeryville, CA (US);
Angelica Medina-selby, San Francisco, CA (US);
Doris Coit, Petaluma, CA (US);
Michael Houghton, Danville, CA (US);
Yin-Ling Lin, Emeryville, CA (US);
Angelica Medina-Selby, San Francisco, CA (US);
Doris Coit, Petaluma, CA (US);
Novartis AG, Basel, CH;
Abstract
The invention provides HCV fusion polypeptides including truncated or full-length HCV NS5 polypeptides, and a portion of the HCV NS2 polypeptide, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating an immune response to HCV, for example a cellular immune response to HCV, such as activating hepatitis C virus (HCV)-specific T cells, including CD4+ and CD8+ T cells. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize against HCV.