The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2012
Filed:
Aug. 21, 2009
Thomas J. Kipps, San Diego, CA (US);
Tetsuya Fukuda, Yokohama, JP;
Tomoyuki Endo, San Diego, CA (US);
Suping Zhang, San Diego, CA (US);
Liguang Chen, San Diego, CA (US);
H. Elizabeth Broome, Lakeside, CA (US);
Thomas J. Kipps, San Diego, CA (US);
Tetsuya Fukuda, Yokohama, JP;
Tomoyuki Endo, San Diego, CA (US);
Suping Zhang, San Diego, CA (US);
Liguang Chen, San Diego, CA (US);
H. Elizabeth Broome, Lakeside, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Compositions comprising a purified and/or isolated antibody, humanized antibodies, precipitates and anti-sera that specifically bind to or are otherwise directed against ROR1 protein. The compositions may be used for detecting ROR1 in a sample from a subject that is suspected or known to contain cancer cells. The ROR1 antibodies are especially useful in identifying and treating lymphomas and ademocarcinomas. Vaccines and related methods for protecting a subject against diseases that involve expression of ROR1 are also provided, as are human anti-sera effective in abrogating interactions between Wnt5a protein and ROR1 that contribute to the survival of certain cancer cells, such as CLL cells.