The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2012
Filed:
Apr. 24, 2007
Alan Hornsby Davidson, Abingdon, GB;
Alan Hornsby Davidson, Abingdon, GB;
Chroma Therapeutics Ltd., Abingdon, Oxfordshire, GB;
Abstract
Compounds of formula (I) or (II) are dihydrofolate reductase inhibitors, useful for the treatment of, for example, cell proliferative diseases: wherein A and D are independently —CHR— or —NR—; E and G are independently ═CR— or ═N—; each Rindependently represents hydrogen or —OR; Ris hydrogen or C-Calkyl; Ris a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; Ris the side chain of a natural or non-natural alpha amino acid which does not contain a carboxyl, or carboxyl ester group; Y is a bond, —C(═O)—, —S(═O)—, —C(═O)NR—, —C(═S)—NR, —C(═NH)NRor —S(═O)NR— wherein Ris hydrogen or optionally substituted C-Calkyl; Lis a divalent radical of formula -(Alk)(Q)(Alk)- wherein m, n and p are independently 0 or 1, and Q, Alkand Alkare as defined in the claims; Xrepresents a bond; —C(═O); or —S(═O)—; —NRC(═O)—, —C(═O)NR—, —NRC(═O)NR—, —NRS(═O)—, or —S(═O)NR— wherein Rand Rare independently hydrogen or optionally substituted C-Calkyl; and z is 0 or 1.