The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2012
Filed:
Sep. 07, 2010
Michael R. Johnson, Chapel Hill, NC (US);
Bruce F. Molino, Slingerlands, NY (US);
Bruce Sargent, Delmar, NY (US);
Jianzhong Zhang, Rensselaer, NY (US);
Michael R. Johnson, Chapel Hill, NC (US);
Bruce F. Molino, Slingerlands, NY (US);
Bruce Sargent, Delmar, NY (US);
Jianzhong Zhang, Rensselaer, NY (US);
Parion Sciences, Inc., Durham, NC (US);
Abstract
The present application relates to pyrazinoyl guanidine sodium channel blockers having the structure: or a pharmaceutically acceptable salt thereof, where the structural variables are as defined herein. The present invention also relates pharmaceutical compositions comprising the sodium channel blockers and their use in methods of treatment, including the treatment of cardiovascular disease, cystic fibrosis, and chronic bronchitis and in the rehydration of mucosal surfaces and promotion of mucus clearance in a patient.