The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2012
Filed:
Mar. 16, 2011
Yoshikazu Yonemitsu, Fukuoka, JP;
Katsuo Sueishi, Fukuoka, JP;
Masayuki Fukumura, Ikeda, JP;
Xiaogang Hou, Alhambra, CA (US);
Mamoru Hasegawa, Tsukuba, JP;
Hidenori Matsusaka, Fukuoka, JP;
Hiroyuki Tsutsui, Fukuoka, JP;
Yoshikazu Yonemitsu, Fukuoka, JP;
Katsuo Sueishi, Fukuoka, JP;
Masayuki Fukumura, Ikeda, JP;
Xiaogang Hou, Alhambra, CA (US);
Mamoru Hasegawa, Tsukuba, JP;
Hidenori Matsusaka, Fukuoka, JP;
Hiroyuki Tsutsui, Fukuoka, JP;
DNAVEC Research Inc., Ibaraki, JP;
Abstract
The present invention provides Paramyxovirus vectors encoding angiogenic genes and use of the same. The use of Paramyxovirus vectors enables effective transfer of angiogenic genes into individual tissues. FGF2 gene transferred into ischemic tissues in vivo induces expression of angiogenic genes without causing edema, and prevents necrosis due to ischemia. The vectors of the present invention are suitable for gene therapy targeted to ischemic tissues.