The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2012
Filed:
Jun. 03, 2010
Hendrik Knoetgen, Penzberg, DE;
Hans-willi Krell, Penzberg, DE;
Sandra Miller, Munich, DE;
Jens Niewoehner, Munich, DE;
Dirk Ponsel, Germering, DE;
Engin Toksoez, Munich, DE;
Hendrik Knoetgen, Penzberg, DE;
Hans-Willi Krell, Penzberg, DE;
Sandra Miller, Munich, DE;
Jens Niewoehner, Munich, DE;
Dirk Ponsel, Germering, DE;
Engin Toksoez, Munich, DE;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
Disclosed herein are methods for the recombinant expression of mammalian cell membrane-bound human CCN1 or a CCN1 domain thereof in mammalian cells, comprising transforming a mammalian host cell with a vector encoding CCN1 or a CCN1 domain thereof C-terminally fused to a mammalian cell transmembrane domain (CCN1 fusion protein), expressing said CCN1 or CCN1 domain fusion protein in said host cell, and recovering said membrane bound CCN1 or said CCN1 domain thereof. Disclosed herein is the use of such membrane bound CCN1 and domain for the generation of corresponding antibodies. Antibodies against human CCN1 are useful for the treatment of diseases.