The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 26, 2012

Filed:

Jul. 16, 2008
Applicants:

Mengwei HU, Washington Township, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Michael P. Dwyer, Scotch Plains, NJ (US);

Arthur G. Taveras, Southborough, MA (US);

Agnes Kim-meade, Fanwood, NJ (US);

Jianguo Yin, Plainsboro, NJ (US);

Xiaoyong Fu, Edison, NJ (US);

Timothy L. Mcallister, Westfield, NJ (US);

Shuyi Zhang, Parsipanny, NJ (US);

Kevin Klopfer, Flemington, NJ (US);

Inventors:

Mengwei Hu, Washington Township, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Michael P. Dwyer, Scotch Plains, NJ (US);

Arthur G. Taveras, Southborough, MA (US);

Agnes Kim-Meade, Fanwood, NJ (US);

Jianguo Yin, Plainsboro, NJ (US);

Xiaoyong Fu, Edison, NJ (US);

Timothy L. McAllister, Westfield, NJ (US);

Shuyi Zhang, Parsipanny, NJ (US);

Kevin Klopfer, Flemington, NJ (US);

Assignee:

Schering Corporation, Kenilworth, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/341 (2006.01); C07D 307/504 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed to formulations, methods of treatment, and processes of synthesis of these polymorphic forms.


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