The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2012
Filed:
Nov. 23, 2007
Ermes Vanotti, Milan, IT;
Marina Caldarelli, Milan, IT;
Francesco Casuscelli, Milan, IT;
Barbara Forte, Milan, IT;
Maria Menichincheri, Milan, IT;
Alessandra Scolaro, Milan, IT;
Gabriella Traquandi, Milan, IT;
Paola Vianello, Milan, IT;
Ermes Vanotti, Milan, IT;
Marina Caldarelli, Milan, IT;
Francesco Casuscelli, Milan, IT;
Barbara Forte, Milan, IT;
Maria Menichincheri, Milan, IT;
Alessandra Scolaro, Milan, IT;
Gabriella Traquandi, Milan, IT;
Paola Vianello, Milan, IT;
Nerviano Medical Sciences S.R.L., Nerviano (MI), IT;
Abstract
The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine,means either simple or double carbon-carbon bond and R, Rand Rare as defined in the specification. Further objects of the invention are a process for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Cdc7 and AKT kinase activity, like cancer.