The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2012
Filed:
Jul. 30, 2002
Eric U. Selker, Eugene, OR (US);
Cindy B. Matsen, Chicago, IL (US);
Peter A. Jones, La Canada, CA (US);
Jonathan Cheng, Alhambra, CA (US);
Sheldon B. Greer, Aventura, FL (US);
Victor E. Marquez, Montgomery Village, MD (US);
Eric U. Selker, Eugene, OR (US);
Cindy B. Matsen, Chicago, IL (US);
Peter A. Jones, La Canada, CA (US);
Jonathan Cheng, Alhambra, CA (US);
Sheldon B. Greer, Aventura, FL (US);
Victor E. Marquez, Montgomery Village, MD (US);
The United States of America as represented by the Secretary of the Department of Health and Human Services, Washington, DC (US);
University of Oregon, Eugene, OR (US);
University of Miami School of Medicine, Miami, FL (US);
University of Sounthern California, Los Angeles, CA (US);
University of Miami, Miami, FL (US);
Abstract
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.