The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2012
Filed:
Sep. 01, 2005
Nicole Suciu-foca, New York, NY (US);
Luigi Scotto, Stamford, CT (US);
Seunghee Kim-schulze, Tenafly, NJ (US);
George Vlad, Forest Hills, NY (US);
Raffaello Cortesini, New York, NY (US);
Nicole Suciu-Foca, New York, NY (US);
Luigi Scotto, Stamford, CT (US);
Seunghee Kim-Schulze, Tenafly, NJ (US);
George Vlad, Forest Hills, NY (US);
Raffaello Cortesini, New York, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention.