The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2012
Filed:
Jul. 09, 2009
Vijay Chauhan, Mumbai, IN;
Ashish Suthar, Mumbai, IN;
Dhananjay Sapre, Mumbai, IN;
Swati Bal-tembe, Mumbai, IN;
Ashok Kumar Gangopadhyay, Mumbai, IN;
Asha Kulkarni-almeida, Mumbai, IN;
Sapna Hasit Parikh, Mumbai, IN;
Ravindra Dattatraya Gupte, Mumbai, IN;
Nilesh Madhukar Dagia, Mumbai, IN;
Somesh Sharma, Mumbai, IN;
Shruta Sudheer Dadarkar, Mumbai, IN;
Mahesh Gundaji Jadhav, Mumbai, IN;
Aditi Amol Tannu, Mumbai, IN;
Vijay Chauhan, Mumbai, IN;
Ashish Suthar, Mumbai, IN;
Dhananjay Sapre, Mumbai, IN;
Swati Bal-Tembe, Mumbai, IN;
Ashok Kumar Gangopadhyay, Mumbai, IN;
Asha Kulkarni-Almeida, Mumbai, IN;
Sapna Hasit Parikh, Mumbai, IN;
Ravindra Dattatraya Gupte, Mumbai, IN;
Nilesh Madhukar Dagia, Mumbai, IN;
Somesh Sharma, Mumbai, IN;
Shruta Sudheer Dadarkar, Mumbai, IN;
Mahesh Gundaji Jadhav, Mumbai, IN;
Aditi Amol Tannu, Mumbai, IN;
Piramal Life Sciences Limited, Mumbai, IN;
Abstract
This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant,. The said extract ofcontains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor-(TNF-α) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1), vascular-cell adhesion molecule 1 (VCAM-1), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti-inflammatory agent or can be used in combination with at least one anti-inflammatory agent.