The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 26, 2012

Filed:

Feb. 10, 2004
Applicants:

Scott A. Waldman, Ardmore, PA (US);

Giovanni Mario Pitari, Philadelphia, PA (US);

Jason Park, Philadelphia, PA (US);

Stephanie Schulz, West Chester, PA (US);

Henry R. Wolfe, Glenmoore, PA (US);

Wilhelm Lubbe, Philadelphia, PA (US);

Inventors:

Scott A. Waldman, Ardmore, PA (US);

Giovanni Mario Pitari, Philadelphia, PA (US);

Jason Park, Philadelphia, PA (US);

Stephanie Schulz, West Chester, PA (US);

Henry R. Wolfe, Glenmoore, PA (US);

Wilhelm Lubbe, Philadelphia, PA (US);

Assignee:

Thomas Jefferson University, Philadelphia, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01); A61P 43/00 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed.


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