The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2012
Filed:
Sep. 10, 2009
Susan M. Freier, San Diego, CA (US);
Olga Matveeva, Salt Lake City, UT (US);
Alexander Tsodikov, Salt Lake City, UT (US);
Michael C. Giddings, Salt Lake City, UT (US);
Jacqueline R. Wyatt, Sundance, WY (US);
Susan M. Freier, San Diego, CA (US);
Olga Matveeva, Salt Lake City, UT (US);
Alexander Tsodikov, Salt Lake City, UT (US);
Michael C. Giddings, Salt Lake City, UT (US);
Jacqueline R. Wyatt, Sundance, WY (US);
Isis Phramaceuticals, Inc., Carlsbad, CA (US);
Abstract
Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.