The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2012
Filed:
Jan. 19, 2011
Robert Mckay, Poway, CA (US);
Ravi Jain, Fremont, CA (US);
Kenneth W. Dobie, Del Mar, CA (US);
Sanjay K. Pandey, Encinitas, CA (US);
Sanjay Bhanot, Carlsbad, CA (US);
Robert McKay, Poway, CA (US);
Ravi Jain, Fremont, CA (US);
Kenneth W. Dobie, Del Mar, CA (US);
Sanjay K. Pandey, Encinitas, CA (US);
Sanjay Bhanot, Carlsbad, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.