The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2012
Filed:
Dec. 22, 2005
Paul E. Kosnik, Honolulu, HI (US);
Christopher T. England, Kapolei, HI (US);
Robert G. Dennis, Chapel Hill, NC (US);
Stuart K. Williams, Tucson, AZ (US);
Paul E. Kosnik, Honolulu, HI (US);
Christopher T. England, Kapolei, HI (US);
Robert G. Dennis, Chapel Hill, NC (US);
Stuart K. Williams, Tucson, AZ (US);
Tissue Genesis Incorporated, Honolulu, HI (US);
Abstract
Tissue engineering methods and biochamber apparatus are provided for making tissue grafts for implantation into a patient. The methods include applying a sustained low magnitude pressure gradient transmurally across a permeable scaffold material using a media containing cells, preferably microvascular epithelial cells, to be deposited on the scaffold for the production of tissue grafts, preferably vascular grafts, to promote accelerated adhesion and maturation of cells on the scaffold material. Biochambers for preparing tubular tissue grafts are provided which contain connectors for holding a graft substrate, proximal and distal tubing for connection to an optional perfusion system, and structure for switching between transmural flow of a cell suspension across the graft substrate and translumenal flow through the lumen of the graft.