The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2012
Filed:
Jun. 06, 2008
Kenji Yasuda, Tokyo, JP;
Atsushi Sugiyama, Fuefuki, JP;
Kentaro Ando, Yachiyo, JP;
Fumimasa Nomura, Tokyo, JP;
Hideyuki Terazono, Tokyo, JP;
Tomoyuki Kaneko, Mitaka, JP;
Mamoru Fukushima, Hachioji, JP;
Kenji Yasuda, Tokyo, JP;
Atsushi Sugiyama, Fuefuki, JP;
Kentaro Ando, Yachiyo, JP;
Fumimasa Nomura, Tokyo, JP;
Hideyuki Terazono, Tokyo, JP;
Tomoyuki Kaneko, Mitaka, JP;
Mamoru Fukushima, Hachioji, JP;
Abstract
The present invention provides an apparatus for evaluating a drug effect enabling on-chip evaluation of the effect of a drug while the drug is acting on hERG-expressing cells. The present invention also provides a myocardial toxicity test apparatus and method therefor enabling in vitro myocardial toxicity testing that has previously been performed in vivo. A pulsating cell population and hERG-expressing cells (target model cells) are suitably isolated and arranged on a transparent substrate so that the two form gap junctions. The hERG-expressing cells are arranged on transparent electrodes provided on the transparent substrate. The hERG-expressing cells are exposed to a flow of a liquid containing a drug such that the drug acts thereon. The difference between the normal pulsation of hERG-expressing cells and the pulsation when a drug is acting thereon is captured via electric signals obtained from electrodes, and the properties of the change in potential are evaluated.