The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2012
Filed:
Sep. 18, 2009
Applicants:
Rao Papineni, Branford, CT (US);
Tao Ji, Hamden, CT (US);
William E. Mclaughlin, Guilford, CT (US);
Inventors:
Assignee:
Carestream Health, Inc., Rochester, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/87 (2006.01); C07H 21/02 (2006.01); C07K 2/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Non-viral vectors for delivering agents to a site within the body of an animal comprise a biocompatible nanoparticle conjugated to an avidin/biotin complex and a water soluble linear polymer comprising multiple binding sites. The agents to be delivered are conjugated to each of the multiple binding sites, thereby increasing the loading capacity of the system. Where the agents comprise siRNA, each biotin/avidin complex may carry greater than four siRNA. The biocompatible nanoparticle may also comprise a fluorescent dye for in vivo imaging.