The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2012
Filed:
Apr. 09, 2010
George Wu, Basking Ridge, NJ (US);
Frank X. Chen, Plainsboro, NJ (US);
Paitoon Rashatasakhon, Samutsakhon, TH;
Jeffrey M. Eckert, Hazlet, NJ (US);
George S. K. Wong, Summit, NJ (US);
Hong-chang Lee, Livingston, NJ (US);
Nolan C. Erickson, West Orange, NJ (US);
Jennifer Ann Vance, Scotch Plains, NJ (US);
Peter C. Nirchio, Lebanon, NJ (US);
Juergen Weber, East Windsor, NJ (US);
David Jieh-shyh Tsai, Warren, NJ (US);
Nanfei Zou, East Brunswick, NJ (US);
George Wu, Basking Ridge, NJ (US);
Frank X. Chen, Plainsboro, NJ (US);
Paitoon Rashatasakhon, Samutsakhon, TH;
Jeffrey M. Eckert, Hazlet, NJ (US);
George S. K. Wong, Summit, NJ (US);
Hong-Chang Lee, Livingston, NJ (US);
Nolan C. Erickson, West Orange, NJ (US);
Jennifer Ann Vance, Scotch Plains, NJ (US);
Peter C. Nirchio, Lebanon, NJ (US);
Juergen Weber, East Windsor, NJ (US);
David Jieh-Shyh Tsai, Warren, NJ (US);
Nanfei Zou, East Brunswick, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
The present invention provides for a process for preparing racemic methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate, its corresponding salt: (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-D-tartaric acid ('D-DTTA') salt or a (1S,2R,5R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-L-tartaric acid salt ('L-DTTA') in a high enantiomeric excess. This invention also provides for a process for preparing a (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate dibenzoyl-D-tartaric acid (“D-DBTA”) salt or a (1S,2R,5R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate L-tartaric acid (“L-DBTA”) salt in a high enantiomeric excess. Further, this invention provides a process for preparing intermediates II, IIB, III, IV, IV salt, V, VI, and VII.