The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2012
Filed:
Aug. 15, 2005
Tak-hang Chan, Hung Hom, HK;
Wai-har Lam, Hung Hom, HK;
Larry Ming-cheung Chow, Hung Hom, HK;
Qing Ping Dou, Detroit, MI (US);
Deborah Joyce Kuhn, Detroit, MI (US);
Aslamuzzaman Kazi, Tampa, FL (US);
Sheng Biao Wan, Hung Hom, HK;
Kristin R. Landis-piwowar, Detroit, MI (US);
Tak-Hang Chan, Hung Hom, HK;
Wai-Har Lam, Hung Hom, HK;
Larry Ming-Cheung Chow, Hung Hom, HK;
Qing Ping Dou, Detroit, MI (US);
Deborah Joyce Kuhn, Detroit, MI (US);
Aslamuzzaman Kazi, Tampa, FL (US);
Sheng Biao Wan, Hung Hom, HK;
Kristin R. Landis-Piwowar, Detroit, MI (US);
The Hong Kong Polytechnic University, Hung Hom, Kowloon, HK;
Wayne State University, Detroit, MI (US);
University of South Florida, Tampa, FL (US);
Abstract
(−)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (−)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formulae below, wherein R, R, R, R, R, R, R, and Rare each independently selected from the group consisting of —H, and Cto Cacyloxyl group; and Ris selected from the group consisting of —H, C-C-alkyl, C-C-alkenyl, C-C-alkynyl, C-C-cycloalkyl, phenyl, benzyl and C-C-cycloalkenyl, whereas each of the last mentioned 7 groups can be substituted with any combination of one to six halogen atoms; at least one of R, R, R, R, R, R, Rand Ris —H, which were found to be more potent than their non-protected counterparts, which can be used as proteasome inhibitors to reduce tumor cell growth.