The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2012
Filed:
Jul. 25, 2007
Satoru Kogo, Choshi, JP;
Kohei Yamada, Choshi, JP;
Yuko Iwai, Koto-ku, JP;
Kazuomi Osawa, Choshi, JP;
Hiroyuki Hayakawa, Choshi, JP;
Satoru Kogo, Choshi, JP;
Kohei Yamada, Choshi, JP;
Yuko Iwai, Koto-ku, JP;
Kazuomi Osawa, Choshi, JP;
Hiroyuki Hayakawa, Choshi, JP;
Yamasa Corporation, Choshi-shi, JP;
Abstract
A di(pyrimidine nucleoside 5'-)polyphosphate is synthesized by converting a pyrimidine nucleoside 5′-triphosphate into a pyrimidine nucleoside 5′-cyclic triphosphate by use of a condensing agent, and subsequently reacting the pyrimidine nucleoside 5′-cyclic triphosphate with a pyrimidine nucleotide in the presence of a salt of a metal selected from among magnesium, manganese, and iron. Through the method of the invention, a di(pyrimidine nucleoside 5′-)polyphosphate can be synthesized from an unprotected pyrimidine nucleoside 5′-phosphate serving as a starting material at a synthesis yield of 50% or higher. Therefore, the method of the invention is suitable for large-scale synthesis of a di(pyrimidine nucleoside 5′-)polyphosphate.