The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2012
Filed:
Mar. 26, 2008
Ali Can, Troy, NY (US);
Michael John Gerdes, Albany, NY (US);
Musodiq Olatayo Bello, Niskayuna, NY (US);
Xiaodong Tao, Niskayuna, NY (US);
Ali Can, Troy, NY (US);
Michael John Gerdes, Albany, NY (US);
Musodiq Olatayo Bello, Niskayuna, NY (US);
Xiaodong Tao, Niskayuna, NY (US);
General Electric Company, Niskayuna, NY (US);
Abstract
The present techniques provide fully automated methods for quantifying the location, strength and percent of expressed target molecules or other biological markers in immunohistochemically stained biological samples. The samples may be automatically segmented, for example into subcellular compartments, from images of compartmental markers. Then, the distribution of a target molecule on each of these compartments is calculated that includes the percentage and strength of expression. This is different than existing intensity or ratio based methods where abundant low expression levels are indistinguishable from scarce high expression levels.