The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2012
Filed:
Jun. 17, 2009
Hartmut Strobel, Frankfurt am Main, DE;
Paulus Wohlfart, Frankfurt am Main, DE;
Heinz-werner Kleemann, Frankfurt am Main, DE;
Gerhard Zoller, Schöneck, DE;
David William Will, Frankfurt am Main, DE;
Hartmut Strobel, Frankfurt am Main, DE;
Paulus Wohlfart, Frankfurt am Main, DE;
Heinz-Werner Kleemann, Frankfurt am Main, DE;
Gerhard Zoller, Schöneck, DE;
David William Will, Frankfurt am Main, DE;
Sanofi-Aventis, Paris, FR;
Abstract
The present invention relates to heteroaryl-substituted carboxamides of the formula I, in which Het, A, X, R, Rand Rhave the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO) synthase and are valuable pharmacologically active compounds. Specifically, the compounds of the formula I upregulate the expression of the enzyme endothelial NO synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention further relates to processes for the preparation of compounds of the formula I, to pharmaceutical compositions comprising them, and to the use of compounds of the formula I for the manufacture of a medicament for the stimulation of the expression of endothelial NO synthase or for the treatment of various diseases including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency, for example.