The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2012
Filed:
Nov. 17, 2006
Applicants:
Jens Pohl, Hambruecken, DE;
Frank Ploeger, Heidelberg, DE;
Michael Kruse, Mainz, DE;
Inventors:
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/51 (2006.01); A61K 38/18 (2006.01); C07H 21/04 (2006.01); C12N 15/00 (2006.01); C12N 1/21 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The application relates to novel biosynthetic growth factor mutants, derived from GDF-5, which exhibit improved biological activity. Mutations at positions 453 and 456 of human GDF-5 are disclosed, as well as use of these mutants in therapy of diseases associated with tissue degeneration/destruction.