The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2012
Filed:
Mar. 12, 2008
Robert C. Moschel, Frederick, MD (US);
Matthew Karl Moschel, Legal Representative, Baltimore, MD (US);
Anthony E. Pegg, Hershey, PA (US);
Sahar Javanmard, Potomac, MD (US);
Natalia Loktionova, Elizabeth Town, PA (US);
Gary Pauly, Frederick, MD (US);
Robert C. Moschel, Frederick, MD (US);
Matthew Karl Moschel, legal representative, Baltimore, MD (US);
Anthony E. Pegg, Hershey, PA (US);
Sahar Javanmard, Potomac, MD (US);
Natalia Loktionova, Elizabeth Town, PA (US);
Gary Pauly, Frederick, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
The Penn State Research Foundation, University Park, PA (US);
Abstract
Disclosed are compounds that are AGT inactivators that include a folate residue, e.g., a compound of formula (I), wherein X, X, R, and Rare as described herein. Also disclosed is a pharmaceutical composition comprising a compound of the invention and a pharmaceutically acceptable carrier. Also disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells and inactivating AGT in a tumor cell. The methods comprise, inter alia, administering a compound or pharmaceutically acceptable salt of formula (I).