The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2012
Filed:
Aug. 15, 2005
Stephen Dalton, Athens, GA (US);
Allan Sheppard, Cambridge, NZ;
Karen Jones, Heidelberg, AU;
E. Edward Baetge, Encinitas, CA (US);
Kevin A. D'amour, San Diego, CA (US);
Alan D. Agulnick, San Marcos, CA (US);
Stephen Dalton, Athens, GA (US);
Allan Sheppard, Cambridge, NZ;
Karen Jones, Heidelberg, AU;
E. Edward Baetge, Encinitas, CA (US);
Kevin A. D'Amour, San Diego, CA (US);
Alan D. Agulnick, San Marcos, CA (US);
University of Georgia Research Foundation, Inc., San Diego, CA (US);
ViaCyte, Inc., San Diego, CA (US);
Abstract
The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free conditions in cell culture and further contacting the cells with an inhibitor of the PI3-kinase pathway and a member of the TGFb family for the generation of differentiated mammalian cells from pluripotent mammalian stem cells. Preferably, the differentiated cell is selected from the group consisting of a mesendodermal cell, a mesodermal cell, and an endodermal cell.