The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2012
Filed:
Oct. 20, 2011
James M. Allen, Seattle, WA (US);
Thomas W. Dubensky, Jr., Seattle, WA (US);
Jin Zhong LI, Belmont, CA (US);
Derek D. Sloan, Seattle, WA (US);
Neal Van Hoeven, Seattle, WA (US);
James M. Allen, Seattle, WA (US);
Thomas W. Dubensky, Jr., Seattle, WA (US);
Jin Zhong Li, Belmont, CA (US);
Derek D. Sloan, Seattle, WA (US);
Neal Van Hoeven, Seattle, WA (US);
Immune Design Corp., Seattle, WA (US);
Abstract
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).